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王明齐 副教授

作者: 时间:2019-06-20 点击数:

   

王明齐,19875月生,博士,副教授,硕士生导师。2014年毕业于四川大学化学学院,师从余孝其教授。主要研究方向为生物有机化学。作为负责人先后主持中国博士后基金、江苏省自然基金、亚游ag官网登录高级人才启动基金等。已在Nucleic Acids Res., Chem. Comm., J. Org. Chem., Org. Biomol. Chem., Bioorg. Med. Chem., New J. Chem., Dyes and Pigments, Analyst等国际知名学术期刊上共发表SCI收录学术论文20余篇;授权中国发明专利2项。同时担任国际国内重要刊物的论文评审专家,包括Sensor Actuat B-ChemSci Rep-UKEur J Med Chem等国际化学领域主流期刊。

E-mail: wmq3415@163.com  Tel: 13705283631




教育经历:

2005.09-2009.06 淮阴师范学院,化学专业,获学士学位

2009.09-2014.07 四川大学,有机化学专业,获博士学位


工作经历:

2012.06-2013.01冈山大学(Okayama University),日本,国际交流合作

2014.07-至今 亚游ag官网登录 讲师

2016.12-至今 亚游ag官网登录,博士后


科研项目(项目负责人):

1、 端粒G4-DNA为靶点的喹啉类衍生物结构修饰及机理研究,中国博士后科学基金,主持

2、 端粒DNA识别分子的核酸调控及相关信号转导干预研究,江苏高等学校自然科学研究面上项目,主持

3、 基于深红/近红外两亲性BODIPY荧光分子自组装:分子设计、G-四链体DNA识别与生物应用,江苏省青年科学基金,主持

4、 G-四链体DNA荧光探针分子的设计合成及其抗肿瘤活性研究,亚游ag官网登录高级人才启动,主持,已结题


研究方向:

1、 核酸药物化学和核酸化学生物学

2、 自组装荧光纳米探针

      3、化学生物传感


代表性论著(第一作者和通讯作者论文):

[1] Wang Ming-Qi*, Xu Jing, Zhang Lan, Liao Yue, Wei Heng, Yin Ying-Ying, Liu Qiang*, Zhang Lan. Tuning the selectivity of N-alkylated styrylquinolinium dyes for sensing of G-quadruplex DNA. Bioorganic & Medicinal Chemistry, 2019, 27: 552–559.

[2] Wang Ming-Qi*, Ren Gui-Ying, Zhao Shuang, Lian Guang-Chang, Chen Ting-Ting, Ci Yang, Li Hong-Yao. Development of a carbazole-based fluorescence probe for G-quadruplex DNA: The importance of side-group effect on binding specificity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018,199, 441–447.

[3] Zhang Feng, Li Gan, Lv Fang-Lei, Jiang Guang-Bin, Wang Han-Xiang, Wang Ming-Qi*, Li Shuo*. A far-red fluorescent probe for selective G-quadruplex DNA targeting. Tetrahedron Letters 2018, 59, 3272–3278.

[4] Wang Ming-Qi*, Liu Xiao-Ning, Guo Zhong-Jian*, Feng chunlai*, Rui mengjie, Synthesis of quinolinium-based probes and studies of their effects for selective G-quadruplex DNA targeting, New Journal of Chemistry, 2018, 42: 4933-4939.

[5] Wang Ming-Qi*, Wu Yuan, Wang Zi-Yu, Chen Qiu-Yun*, Xiao Fu-Yan, Jiang Yu-Chi, Sang Amy, G-quadruplex DNA fluorescence sensing by a bis-amine-substituted styrylquinolinium dye, Dyes and Pigments, 2017, 145: 1-6.

[6] Wang Ming-Qi*, Wang Zi-Yu, Yang Yi-Fan, Ren Gui-Ying, Liu Xiao-Ning, Li Shuo*, Wei Jian-Wei, Zhang Lan, Development of a light-up fluorescent probe for HRAS G-quadruplex DNA. Tetrahedron Letters, 2017, 58: 3296-3300.

[7] Wang Ming-Qi*, Liu Shuo, Tang Cai-Ping, Raza Aun, Li Shuo*, Gao Lie-Xiong, Sun Jing*, Guo Song-Ping, Flexible amine-functionalized triphenylamine derivative as a fluorescent “light-up” probe for G-quadruplex DNA, Dyes and Pigments, 2017, 136: 78-84.

[8] Wang Ming-Qi, Gao Lie-Xiong, Yang Yi-Fan, Xiong Xian-Ning, Zheng Zhao-Yi, Li Shuo*, Wu Yuan, Ma Lu-Lu, A triphenylamine derivative as a naked-eye and light-up fluorescent probe for G-quadruplex DNA, Tetrahedron Letters, 2016, 57(46): 5042-5046.

[9] Wang Ming-Qi*, Dong Juan, Zhang Huafan, Tang Zhuo*.Characterization of deoxyribozymes with site-specific oxidative cleavage activity against DNA obtained by in vitro selection, Organic & Biomolecular Chemistry, 2016, 14(7): 2347-2351.

[10] Wang Ming-Qi*, Zhu Wen-Xiang, Song Zhuan-Zhuan, Li Shuo*, Zhang Yong-Zhao, A triphenylamine-based colorimetric and fluorescent probe with donor–bridge–acceptor structure for detection of G-quadruplex DNA, Bioorganic & Medicinal Chemistry Letters, 2015, 25(24): 5672-5676.

[11] Wang Ming-Qi, Zhang Hua-Fan, Zhang Wei, Zhao Yong-yun, Yasmeen Afshan, Zhou Li, Yu Xiao-Qi*, Tang Zhuo*, In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity, Nucleic Acids Research, 2014, 42(14): 9262-9269.

[12] Wang Ming-Qi, Li Kun*, Xu Hao-Ran, Yu Xiao-Qi*, Imidazolium-based 1,1’-bi-2-naphthol fluorescent probe for ratiometric and selective detection of DNA in water, Analytical Methods, 2013, 5(21): 5903-5907.

[13] Wang Ming-Qi, Li Kun*, Hou Li-Ting, Wu Ming-Yu, Huang Zeng, Yu Xiao-Qi*, BINOL-Based fluorescent sensor for recognition of Cu(II) and sulfide anion in water, Journal of Organic Chemistry, 2012, 77(18): 8350-8354.

[14] Wang Ming-Qi, Zhang Ji, Zhang Yu, Zhang Da-Wei, Liu Qiang, Liu Jun-Liang, Lin Hong-Hui*, Yu Xiao-Qi*, Metal-free cleavage efficiency toward DNA by a novel PNA analog-bridged macrocyclic polyamine, Bioorganic & Medicinal Chemistry Letters, 2011, 21(19): 5866-5869.

[15] Wang Ming-Qi, Liu Jun-Liang, Wang Jing-Yi, Zhang Da-Wei, Zhang Ji, Streckenbach Frank, Tang Zhuo*, Lin Hong-Hui*, Liu Yan, Zhao Yu-Fen, Yu Xiao-Qi*, Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate, Chemical Communications, 2011, 47(39): 11059-11061.


授权发明专利:

[1] 一种具有电荷转移特性的荧光探针及其制备方法和用途。

[2] 一种α-Fe2O3磁性纳米棒的制备方法。

           

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